Banca de QUALIFICAÇÃO: MÔNICA HIPÓLITO DA SILVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE: MÔNICA HIPÓLITO DA SILVA
DATA: 14/06/2024
HORA: 08:30
LOCAL: Auditório do PPGQ/UFPI
TÍTULO: Heterojunction of titanate nanotubes enhanced by curcumin: synthesis, characterization, and evaluation of biological
PALAVRAS-CHAVES: titanate nanotubes; curcumin; heterojunction; biological activity
PÁGINAS: 31
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Inorgânica
ESPECIALIDADE: Química Bio-Inorgânica
RESUMO:

In recent years, much consideration has been given to the benefits of turmeric (Curcuma longa L.). As a result, several studies have reported its anticancer, antioxidant, anti-inflammatory, antibacterial, antidepressant, antidiabetic, antiviral, antifungal, antiparasitic, healing, and digestive properties, among many others. However, it's poor aqueous solubility and low bioavailability limit its utilization. This can be overcome by incorporating curcumin (CCM) into nanoformulations that can penetrate tissues and be more readily absorbed by cells due to their nanometric dimensions. In this work, sodium titanate nanotubes (NaTiNT) were synthesized using the alkaline hydrothermal method and subjected to a heterojunction with CCM. They were then characterized by DRX, FTIR, TG, XPS, and MET techniques, which confirmed the union and also the intact physical integrity of both after the joining. After characterization, biological activities were evaluated using Residual Hemolytic Activity (%HR) and Cytotoxicity Assessment (MTT) assays. The NaTiNT sample exhibited hemolytic activity at a concentration of 50 mg/ml, while the CCM sample showed reduced viability at concentrations of 50 mg/ml and 25 mg/ml, and slightly reduced viability at 6.25 mg/ml. The CCM@TiNT sample, on the other hand, only had a concentration of 1.5625 mg/ml with slight hemolytic activity. In the cytotoxicity test, samples with varying concentrations of NaTiNT and CCM demonstrated reduced overall viability over the course of 48 hours. However, in the meantime, the heterojunction of the two samples, at most concentrations used, exhibited viability similar to that of the control and did not show cytotoxicity to the cells studied. In summary, the results highlight the significant potential of nanoformulations, such as the heterojunction of sodium titanate nanotubes with CCM, to enhance the biological efficacy of turmeric. This promising approach opens doors to more efficient and safer therapeutic applications, representing a significant advance in harnessing the benefits of CCM in healthcare.

MEMBROS DA BANCA:
Presidente - 1714193 - JOSE MILTON ELIAS DE MATOS
Interno - 1074119 - ANTÔNIA LAÍRES DA SILVA SANTOS
Interno - 1614544 - JURANDY DO NASCIMENTO SILVA
Interno - 1508806 - WELTER CANTANHEDE DA SILVA
Externo ao Programa - 029.137.033-05 - JOAO VICTOR BARBOSA MOURA - UFC