Banca de QUALIFICAÇÃO: GUSTAVO FERNANDES DE SOUSA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE: GUSTAVO FERNANDES DE SOUSA
DATA: 08/10/2024
HORA: 14:00
LOCAL: Banca Remota
TÍTULO: Smart Hydrogels for Tissue Regeneration
PALAVRAS-CHAVES: Biomaterials; Click chemistry; Skin tissue engineering; Regenerative medicine.
PÁGINAS: 35
GRANDE ÁREA: Engenharias
ÁREA: Engenharia de Materiais e Metalúrgica
SUBÁREA: Materiais Não-Metálicos
ESPECIALIDADE: Materiais Conjugados Não-Metálicos
RESUMO:

The quest for an ideal biomaterial perfectly matching the microenvironment of the surrounding tissue and cells in an endless challenge within biomedical research, in addition to integrating this with a facile and sustainable technology for its preparation. Engineering hydrogels through click-chemistry would promote the sustainable invention of tailor-made hydrogels. Herein, we disclose a versatile and facile catalyst-free click chemistry for the generation of an innovative hydrogel by combining chondroitin sulfate (CS) and polyethylene glycol (PEG). The combination of different multi-armed PEG-Norbornene (A-PEG-N) with variable molecular sizes was investigated to generate crosslinked copolymers with tunable rheological and mechanical properties. The crosslinked and mechanically stable porous hydrogels could be generated by simply mixing the two clickable Tetrazine-CS (TCS) and APEG-N components, generating a self-standing hydrogel within minutes. The leading candidate (TCS-8A-PEG-N (40 kD)), based on the mechanical and biocompatibility results, was further employed as a scaffold to improve wound closure and blood flow in vivo, The hydrogel demonstrated not only enhanced blood perfusion and an increased number of blood vessels, but also desirable fibrous matrix orientation and normal collagen deposition. Taken together, these results demonstrate the potential of the hydrogel to improve wound repair and hold promise for in situ skin tissue engineering applications.

MEMBROS DA BANCA:
Presidente - 1397472 - ANDERSON DE OLIVEIRA LOBO
Interno - 1570906 - BARTOLOMEU CRUZ VIANA NETO
Externo ao Programa - 1691866 - NAPOLEAO MARTINS ARGOLO NETO