Banca de QUALIFICAÇÃO: CATERINE YESENIA CARRASCO MONTESDEOCA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE: CATERINE YESENIA CARRASCO MONTESDEOCA
DATA: 02/08/2019
HORA: 09:00
LOCAL: Auditorio do PPG em Ciencia e Engenharia dos Materiais
TÍTULO: OXYGEN-RELEASING HYDROGELS ALLOW THE CARTILAGE TISSUE REGENERATION UNDER HYPOXIC CONDITIONS
PALAVRAS-CHAVES: Matrix of methacryloyl gelatin (GelMA), Calcium peroxide (CPO), Release kinetics, chondrocytes cell
PÁGINAS: 35
GRANDE ÁREA: Engenharias
ÁREA: Engenharia de Materiais e Metalúrgica
SUBÁREA: Materiais Não-Metálicos
ESPECIALIDADE: Polímeros, Aplicações
RESUMO:

Cartilage is one of our body tissues that is not repaired automatically by itself. Problems associated to cartilage are very common worldwide and is considered the leading cause of pain and disability. Smart biomaterial or “Four dimensional” (4D) biomaterials has been extensively used and can easily be explained through the capacity of three-dimensional (3D) materials to change their morphology to physiologic stimuli or to generate a response measured at space and time. In this context, the oxygen delivery from the biomaterials upon contact with water is considered 4D biomaterials. This work of investigation has how objective development strategies to delivery oxygen through hydrogels systems to promote cell growth in hypoxia environment. 4D biomaterials were based on gelatin methacryloyl (GelMA) loaded with oxygen delivery nanoparticles (CPO) at different concentrations (0.5, 1 and 3%), by FTIR, and RAMAN the presence of CPO was confirmed, by an optical sensor were identify the oxygen release kinetics. SEM, Rheology and degradation are in progress to confirm the distribution, deformation and weight loss of the hydrogels. The swelling were also evaluated. Finally the result showed a control oxygen release by 6 days with efficiencies (9.8, 10 and 52% respectively). The oxygen release from the hydrogels confirmed a sustained release for up to 6 days. Moreover, the viability of chondrocytes in the hydrogels were investigated showing high viability (>90%). In conclusion, we have disclosed the design and fabrication of the 4D nanogel loaded with functional oxygen generating microparticles for cartilage tissue engineering application

MEMBROS DA BANCA:
Presidente - 1397472 - ANDERSON DE OLIVEIRA LOBO
Interno - 1570906 - BARTOLOMEU CRUZ VIANA NETO
Interno - 1780191 - FRANCISCO ERONI PAZ DOS SANTOS
Externo à Instituição - FRANCILIO DE CARVALHO OLIVEIRA - UNINOVAFAPI