Banca de DEFESA: LEILA SAMARA SANTOS MOREIRA MAGALHÃES

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE: LEILA SAMARA SANTOS MOREIRA MAGALHÃES
DATA: 23/02/2022
HORA: 14:00
LOCAL: Sala remota: meet.google.com/jza-jojf-fji
TÍTULO: APPLICATIONS OF HYDROGELS IN TISSUE ENGINEERING - MICROFABRICATION TECHNIQUES AND IN VITRO APPLICATIONS
PALAVRAS-CHAVES: Hydrogels. Bone Regeneration. Tissue Engineering.
PÁGINAS: 97
GRANDE ÁREA: Engenharias
ÁREA: Engenharia de Materiais e Metalúrgica
SUBÁREA: Materiais Não-Metálicos
ESPECIALIDADE: Polímeros, Aplicações
RESUMO:

Osteoporosis is a disorder characterized by decreased bone mineral density and structural degeneration of bone tissue making it susceptible to fracture [1] [2]. Fractures caused by osteoporosis can cause acute and chronic pain affecting mainly elderly patients, and until the fracture occurs osteoporosis is asymptomatic and often progresses without symptoms [3]. Osteoporosis can occur in men, especially after age 70, and in women after menopause due to declining estrogen levels and osteoporotic fractures are considered a priority in public health, as over 40% of women and 20% of men They are likely to have an osteoporotic fracture during their lifetime. It is estimated that the growth of the elderly population and the risk of osteoporosis will increase 3-fold by 2050 causing excessive health costs [4]. Thus, with increasing life expectancy worldwide, it is expected that the prevalence of osteoporosis will consequently increase. Clinical and therapeutic treatments for osteoporosis are not able to offer long-term solutions to decrease bone loss and increased risk of fracture that are the main features of the disease. The combination of bioactive nanomaterials within a biomaterial framework is promising for the development of long-term localized treatment for people affected with osteoporosis [5]. These biomaterials include structured hydrogels and nanostructured clay particles, especially laponite, which have unique properties with high potential for medical, therapeutic, and diagnostic applications [6]. Laponite is a synthetic hectorite clay consisting of relatively uniform disc-shaped particles of 25 nm in diameter and 1 nm in thickness. Studies have also proven that laponite can induce bone formation even in the absence of any osteoinductive factors [7]. Thus, for bone tissue engineering, among the most sought after are osteoinducers that have the property of inducing ectopic bone formation and bone tissue regeneration [8]. Hydrogels are polymeric networks containing large amounts of water and have been considered excellent candidates for soft tissue engineering scaffolds, including polyethylene glycol diacrylate (PEGDA) which together with laponite improves mechanical properties and allows cell adhesion and its subsequent propagation in a 2D culture and supported 3D cell encapsulation [9]. In this context, Laponite and PEGDA become a useful alternative for the development and manufacture of scaffolds from 3D biofabrication with promising clinical application in bone regeneration therapies and treatments. Thus, this study aims to analyze the effect of laponite and propylene glycol diacrylate (PEGDA) for boné mineralization and repair.

MEMBROS DA BANCA:
Presidente - 1397472 - ANDERSON DE OLIVEIRA LOBO
Interno - 1553988 - EDSON CAVALCANTI DA SILVA FILHO
Interno - 1780191 - FRANCISCO ERONI PAZ DOS SANTOS
Interno - 1722880 - JOSY ANTEVELI OSAJIMA FURTINI
Externo ao Programa - 579.291.143-68 - ANTONIO LUIZ MARTINS MAIA FILHO - UESPI
Externo à Instituição - ANA CLÉCIA SANTOS DE ALCÂNTARA - UFMA